Effect of ranitidine and amoxicillin plus metronidazole on the eradication of Helicobacter pylori and the recurrence of duodenal ulcer.

@article{Hentschel1993EffectOR,
  title={Effect of ranitidine and amoxicillin plus metronidazole on the eradication of Helicobacter pylori and the recurrence of duodenal ulcer.},
  author={E. Hentschel and Gerald Brandst{\"a}tter and Brigitte Dragosics and Alexander M. Hirschl and H Nĕmec and Kurt Schütze and M. Taufer and Herbert Wurzer},
  journal={The New England journal of medicine},
  year={1993},
  volume={328 5},
  pages={
          308-12
        }
}
BACKGROUND Persistent infection with Helicobacter pylori is associated with the recurrence of duodenal ulcer. Whether the efficacy of bismuth therapy in reducing the rate of recurrence of duodenal ulcer is due to its antimicrobial effects on H. pylori or to a direct protective action on the mucosa is still a matter of debate. METHODS To study the effect of the eradication of H. pylori on the recurrence of duodenal ulcer, we treated 104 patients with H. pylori infection and recurrent duodenal… 

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TLDR
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TLDR
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Pretreatment determination of the susceptibility is appropriate in any anti-H.
...

References

SHOWING 1-10 OF 15 REFERENCES

Recurrence of duodenal ulcer and Campylobacter pylori infection after eradication

TLDR
It is concluded that “triple chemotherapy” can achieve long‐term eradication of C. pylori infection effectively in the majority of treated patients and that the recurrence of duodenal ulcers thus may be diminished.

The efficacy of antimicrobial treatment in Campylobacter pylori-associated gastritis and duodenal ulcer.

TLDR
Development of bacterial resistance was observed in patients with additional quinolones, metronidazole and rifampicin but not in patients treated with betalactam antibiotics.

Cure of duodenal ulcer after eradication of Helicobacter pylori

TLDR
It is concluded that duodenal ulcer disease will not recur provided the patient remains free of H. pylori.

Effect of triple therapy (antibiotics plus bismuth) on duodenal ulcer healing. A randomized controlled trial.

TLDR
The results indicate that H. pylori plays a role in duodenal ulcer disease and combined therapy with anti-H.pylori agents and ranitidine was superior to ranitazine alone for duodental ulcers healing.

Pathogenesis of peptic ulcer and implications for therapy.

  • A. Soll
  • Medicine
    The New England journal of medicine
  • 1990
TLDR
Current knowledge about the pathogenesis of peptic ulcers is reviewed, strategies for treatment are discussed and three basic levels of defense underlie the remarkable ability of normal gastroduodenal mucosa to resist injury from the acid and Peptic ulcer attacks.

Eradicating Helicobacter pylori