Effect of ranitidine and amoxicillin plus metronidazole on the eradication of Helicobacter pylori and the recurrence of duodenal ulcer.

  title={Effect of ranitidine and amoxicillin plus metronidazole on the eradication of Helicobacter pylori and the recurrence of duodenal ulcer.},
  author={E. Hentschel and Gerald Brandst{\"a}tter and Brigitte Dragosics and Alexander M. Hirschl and H Nĕmec and Kurt Schütze and M. Taufer and Herbert Wurzer},
  journal={The New England journal of medicine},
  volume={328 5},
BACKGROUND Persistent infection with Helicobacter pylori is associated with the recurrence of duodenal ulcer. Whether the efficacy of bismuth therapy in reducing the rate of recurrence of duodenal ulcer is due to its antimicrobial effects on H. pylori or to a direct protective action on the mucosa is still a matter of debate. METHODS To study the effect of the eradication of H. pylori on the recurrence of duodenal ulcer, we treated 104 patients with H. pylori infection and recurrent duodenal… 

Omeprazole and ranitidine in the prevention of relapse in patients with duodenal ulcer disease.

More duodenal ulcer patients are maintained in remission with omeprazole 20 mg daily than with omEPrazole 10 mg daily or with ranitidine 150 mg at bedtime, reflecting the different degrees of acid inhibition induced by the three treatments.

Triple therapy with ranitidine, clarithromycin, and metronidazole in the treatment of Helicobacter pylori.

Triple therapy with ranitidine, clarithromycin, and metronidazole provides a safe and effective treatment of H. pylori infection, resulting in a high eradication rate, and in significant decrease in semiquantitative histology scores.

Effect of the eradication ofHelicobacter pylori on duodenal ulcer healing and ulcer relapse: Randomized controlled study in Japan

The eradication of H. pylori markedly decreased the relapse rate in duodenal ulcer patients, and it significantly improved both the grade of gastritis and the quality of the ulcer scar.

Symptomatic benefit from eradicating Helicobacter pylori infection in patients with nonulcer dyspepsia.

In patients with H. pylori infection and nonulcer, or functional, dyspepsia, treatment with omeprazole and antibiotics to eradicate the infection is more likely to resolve symptoms than treatment with Omeprazoles alone.

Comparison of Omeprazole, Metronidazole and Clarithromycin with Omeprazole/Amoxicillin Dual-Therapy for the Cure of Helicobacter pylori Infection

It is concluded that combined treatment with omeprazole, clarithromycin and a higher dose of metronidazole is highly effective in curing H. pylori infection, and that this regimen remains very effective in the presence of metronsidazoles-resistant strains.

A new quadruple therapy for the eradication of Helicobacter pylori. Effect of pretreatment with omeprazole on the cure rate

The new quadruple therapy consisting of omeprazole, amoxicillin, metronidazole, and roxithromycin appears suitable for use in clinical practice, as the cure rate was 95% and no severe side effects were observed.

Medium- and high-dose omeprazole plus amoxicillin for eradication ofHelicobacter pylori in duodenal ulcer disease

Omeprazole plus amoxicillin is a highly effective and well-tolerated therapy regimen to eradicateH.

Ranitidine bismuth citrate with clarithromycin for the treatment of duodenal ulcer

Ranitidine bismuth citrate is a well tolerated and efficacious ulcer healing drug which, when co-prescribed with clarithromycin, affords effective H pylorieradication therapy and prevents ulcer relapse in most patients with duodenal ulcer.

Effect of Metronidazole Resistance on Bacterial Eradication of Helicobacter pylori in Infected Children

Pretreatment determination of the susceptibility is appropriate in any anti-H.



Recurrence of duodenal ulcer and Campylobacter pylori infection after eradication

It is concluded that “triple chemotherapy” can achieve long‐term eradication of C. pylori infection effectively in the majority of treated patients and that the recurrence of duodenal ulcers thus may be diminished.

The efficacy of antimicrobial treatment in Campylobacter pylori-associated gastritis and duodenal ulcer.

Development of bacterial resistance was observed in patients with additional quinolones, metronidazole and rifampicin but not in patients treated with betalactam antibiotics.

Cure of duodenal ulcer after eradication of Helicobacter pylori

It is concluded that duodenal ulcer disease will not recur provided the patient remains free of H. pylori.

Effect of triple therapy (antibiotics plus bismuth) on duodenal ulcer healing. A randomized controlled trial.

The results indicate that H. pylori plays a role in duodenal ulcer disease and combined therapy with anti-H.pylori agents and ranitidine was superior to ranitazine alone for duodental ulcers healing.

Pathogenesis of peptic ulcer and implications for therapy.

  • A. Soll
  • Medicine
    The New England journal of medicine
  • 1990
Current knowledge about the pathogenesis of peptic ulcers is reviewed, strategies for treatment are discussed and three basic levels of defense underlie the remarkable ability of normal gastroduodenal mucosa to resist injury from the acid and Peptic ulcer attacks.

Eradicating Helicobacter pylori