Effect of ramosetron on stool consistency in male patients with irritable bowel syndrome with diarrhea.

@article{Fukudo2014EffectOR,
  title={Effect of ramosetron on stool consistency in male patients with irritable bowel syndrome with diarrhea.},
  author={Shin Fukudo and Motoko Ida and Hiraku Akiho and Yoshihiro Nakashima and Kei Matsueda},
  journal={Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association},
  year={2014},
  volume={12 6},
  pages={953-9.e4}
}
BACKGROUND & AIMS Ramosetron, a serotonin (5-hydroxytryptamine)-3 receptor antagonist with high selectivity, reduced stress-induced diarrhea and defecation caused by corticotropin-releasing hormone in rats. However, there have been no clinical trials of its effect in patients with diarrhea and irritable bowel syndrome (IBS-D). We performed a randomized, double-blind, placebo-controlled trial to determine whether ramosetron reduces diarrhea in these patients. METHODS Our study included 296… CONTINUE READING
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