Effect of ramipril and furosemide treatment on interstitial remodeling in post-infarction heart failure rat hearts.

@article{Seeland2002EffectOR,
  title={Effect of ramipril and furosemide treatment on interstitial remodeling in post-infarction heart failure rat hearts.},
  author={U. Seeland and I. Kouchi and O. Zolk and G. Itter and W. Linz and M. B{\"o}hm},
  journal={Journal of molecular and cellular cardiology},
  year={2002},
  volume={34 2},
  pages={
          151-63
        }
}
Extracellular matrix (ECM) remodeling and increased matrix metalloproteinase (MMP) expression and activity have been observed to be relevant in the development of heart failure (HF). We examined the effects of ramipril alone or with furosemide on ECM in a heart failure model. HF was induced by occlusion of the left coronary artery in spontaneously hypertensive rats (SHR). Rats were assigned to placebo (n=9), ramipril 1 mg/kg/day (n=11), furosemide 2 x 2 mg/kg/day (n=7) or both (1 mg/kg/day + 2… Expand
Reduced MMP-2 activity contributes to cardiac fibrosis in experimental diabetic cardiomyopathy
Furosemide induces mortality in a rat model of chronic heart failure.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 32 REFERENCES
Molecular effects of M17055, furosemide and thiazide on cardiac hypertrophy of spontaneously hypertensive rats.
Novel approaches to retard ventricular remodeling in heart failure
  • F. Spinale
  • Medicine
  • European journal of heart failure
  • 1999
Regulation of collagen degradation in the rat myocardium after infarction.
...
1
2
3
4
...