Effect of ramipril and furosemide treatment on interstitial remodeling in post-infarction heart failure rat hearts.

@article{Seeland2002EffectOR,
  title={Effect of ramipril and furosemide treatment on interstitial remodeling in post-infarction heart failure rat hearts.},
  author={Ute Seeland and Ichiro Kouchi and Oliver Zolk and Gabi Itter and Wolfgang Linz and Michael Prof. Dr. B{\"o}hm},
  journal={Journal of molecular and cellular cardiology},
  year={2002},
  volume={34 2},
  pages={
          151-63
        }
}
Extracellular matrix (ECM) remodeling and increased matrix metalloproteinase (MMP) expression and activity have been observed to be relevant in the development of heart failure (HF). We examined the effects of ramipril alone or with furosemide on ECM in a heart failure model. HF was induced by occlusion of the left coronary artery in spontaneously hypertensive rats (SHR). Rats were assigned to placebo (n=9), ramipril 1 mg/kg/day (n=11), furosemide 2 x 2 mg/kg/day (n=7) or both (1 mg/kg/day + 2… CONTINUE READING

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Furosemide induces mortality in a rat model of chronic heart failure.

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