Effect of radiotherapy fraction size on tumour control in patients with early-stage breast cancer after local tumour excision: long-term results of a randomised trial.

@article{Owen2006EffectOR,
  title={Effect of radiotherapy fraction size on tumour control in patients with early-stage breast cancer after local tumour excision: long-term results of a randomised trial.},
  author={John R. Owen and Anita Ashton and Judith Margaret Bliss and Janis Homewood and Caroline Harper and Jane A Hanson and Joanne S. Haviland and Soren M. Bentzen and John R. Yarnold},
  journal={The Lancet. Oncology},
  year={2006},
  volume={7 6},
  pages={467-71}
}
BACKGROUND Standard curative schedules of radiotherapy to the breast deliver 25 fractions of 2.0 Gy over 5 weeks. In a randomised trial, we tested whether fewer, larger fractions were at least as safe and as effective as standard regimens. In this analysis, we assessed the long-term results of tumour control in the same population. METHODS In 1986-98, we randomly assigned 1410 women with invasive breast cancer (tumour stage 1-3 with a maximum of one positive node and no metastasis) who had… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 10 references

High-tech in radiation oncology: should there be a ceiling?

International journal of radiation oncology, biology, physics • 2004

The linear-quadratic model in clincal practice

SM Bentzen, M. Baumann
Steel GG, ed. Basic Clinical Radiobiology. 3rd ed. London: Arnold, • 2002

Group

START Trial Managemen
Standardisation of Breast Radiotherapy (START) Trial. Clin Oncol • 1999

Standardisation of Breast Radiotherapy ( START ) Trial

SM Bentzen
Clin Oncol • 1999

Time-dose factors in radiotherapy: a review of the human data.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology • 1990

The high steepness of dose-response curves for late-responding normal tissues.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology • 1989

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