Effect of race on vincristine-associated neurotoxicity in pediatric acute lymphoblastic leukemia patients.

Abstract

BACKGROUND This report examines the association between race and vincristine-associated neurotoxicity in pediatric patients with precursor B cell acute lymphoblastic leukemia (preB ALL). Given that in vitro vincristine is metabolized more efficiently by cytochrome P450 (CYP) 3A5 than by CYP3A4 and that 70% African-Americans (vs. 20% of Caucasians) express… (More)

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