Effect of quinidine on the intestinal secretion of digoxin in guinea pigs.

@article{Schfer1984EffectOQ,
  title={Effect of quinidine on the intestinal secretion of digoxin in guinea pigs.},
  author={Siegfried G. Sch{\"a}fer and B. Fichtl and W. Doering},
  journal={Biopharmaceutics \& drug disposition},
  year={1984},
  volume={5 2},
  pages={
          163-8
        }
}
Following i.v. injection of digoxin (10 micrograms kg-1) the ratio between digoxin concentrations in the lumen of jejunal loops perfused in situ and in plasma (L/P) of guinea pigs increased linearly with time. After 3 h, L/P was 8.7, indicating net secretion of digoxin against a concentration gradient. In quinidine treated animals (100 mg kg-1 p.o., 2 h before experiment) both the L/P ratio (5.7; p less than 0.01) and the digoxin content of jejunal tissue (-32 per cent; p less than 0.01) were… 
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References

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Tissue binding sites involved in quinidine-cardiac glycoside interactions.

Results indicate that the binding site involved in quinidine-digoxin interaction has a strict structural requirement with respect ot the glycoside, and of the four antiarrhythmic drugs, qu inidine appears to be the only agent which interacts with digoxin.

The Quinidine-Digoxin Interaction in Perspective

The evidence available at present strongly suggests that the increase in serum digoxin concentration in the quinidine-digoxin interaction results at least partially in an increased cardiac effect, and tentative therapeutic recommendations can be given.