Effect of quinidine on the intestinal secretion of digoxin in guinea pigs.

  title={Effect of quinidine on the intestinal secretion of digoxin in guinea pigs.},
  author={Siegfried G. Sch{\"a}fer and B. Fichtl and W. Doering},
  journal={Biopharmaceutics \& drug disposition},
  volume={5 2},
Following i.v. injection of digoxin (10 micrograms kg-1) the ratio between digoxin concentrations in the lumen of jejunal loops perfused in situ and in plasma (L/P) of guinea pigs increased linearly with time. After 3 h, L/P was 8.7, indicating net secretion of digoxin against a concentration gradient. In quinidine treated animals (100 mg kg-1 p.o., 2 h before experiment) both the L/P ratio (5.7; p less than 0.01) and the digoxin content of jejunal tissue (-32 per cent; p less than 0.01) were… 
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Quinidine decreases the intestinal secretion of digoxin and digitoxin in the guinea-pig

The secretion of digoxin and digitoxin into in situ perfused jejunal and colonic segments of normal or quinidine treated guinea-pigs was studied. Quinidine was administered intravenously by constant

The effect of digoxin dosage on the digoxin—quinidine interaction in the bile duct‐cannulated rat

The influence of cardiac glycoside dosage shown by the present work indicates that the digoxin—quinidine interaction and possibly analogous interactions involving other cardiac glyCosides, may not always be readily detectable from plasma concentration data.

The Plasma Disposition and Renal Elimination of Digoxinspecific Fab Fragments and Digoxin in the Rabbit

Administering digoxin‐specific antibody fragments to rabbits 1 h after digoxin produced a redistribution of digoxin associated with a 5‐fold elevation in total plasma concentration and 36–86% reductions in elimination half‐life, apparent volume of distribution at steady‐state and total body clearance (CLT).

Identification and evaluation of Lonicera japonica flos introduced to the Hailuogou area based on ITS sequences and active compounds

The variety H11 was observed to have the highest level of active components, and is therefore recommended for large-scale planting in the Hailuogou area, and the ITS sequence analysis was proven to be highly effective in identifying LJF and Lonicerae flos.



Tissue binding sites involved in quinidine-cardiac glycoside interactions.

Results indicate that the binding site involved in quinidine-digoxin interaction has a strict structural requirement with respect ot the glycoside, and of the four antiarrhythmic drugs, qu inidine appears to be the only agent which interacts with digoxin.

The Quinidine-Digoxin Interaction in Perspective

The evidence available at present strongly suggests that the increase in serum digoxin concentration in the quinidine-digoxin interaction results at least partially in an increased cardiac effect, and tentative therapeutic recommendations can be given.