Effect of quinidine on the digoxin receptor in vitro.

@article{Ball1981EffectOQ,
  title={Effect of quinidine on the digoxin receptor in vitro.},
  author={William James Ball and Doris Tse-Eng and Earl Taylor Wallick and John P. Bilezikian and Arnold Schwartz and Vincent P. Butler},
  journal={The Journal of clinical investigation},
  year={1981},
  volume={68 4},
  pages={
          1065-74
        }
}
To investigate the basis for a clinically important digitalis-quinidine interaction that is characterized by increases in serums digoxin concentrations when quinidine is administered to digoxin-treated patients, we have studied in vitro the interaction of quinidine with the digoxin receptor. Evidence has been obtained that quinidine is capable of decreasing the affinity for digoxin of cardiac glycoside receptor sites on purified Na,K-ATPase and on intact human erythrocyte membranes. As others… 

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Hepatic interaction between quinidine and digoxin: role of inhibition of sinusoidal Na⁺/K⁺ ATPase digoxin binding.

  • Peng LiM. WeissM. Roberts
  • Biology, Medicine
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2012

Effect of quinidine on digoxin distribution and elimination in guinea pigs.

It was concluded that quinidine caused a inhibition ofdigoxin in the tissue binding or uptake, which significantly decreased the Kp values of digoxin; this result may explain the significant decrease of Vdss.

Effect of quinidine on the tissue binding of digoxin in guinea‐pigs

It is concluded that quinidine‐induced decrease in the tissue distribution of digoxin in heart and muscle is due to inhibition of tissue binding of this drug, while that in liver could be partially attributed to the decrease inthe tissue binding.

Myocardial Monovalent Cation Transport during the Quinidine‐Digoxin Interaction in Dogs

During the quinidine-digoxin interaction in the intact dog, the reduction in myocardial rubidium uptake is less than expected from the increase in serum digoxin concentration.

Digoxin‐Quinidine Interaction in Patients with Chronic Renal Failure

In patients with chronic renal failure, the dose of digoxin should be decreased by 50% if quinidine therapy is initiated, and the decrease in total body clearance was due to a decrease in the nonrenal clearance ofDigoxin.

Effect of itraconazole on the pharmacokinetics of digoxin in guinea pigs

The pharmacokinetic interaction between DGX and ITZ may be due not only to a reduction in the renal clearance but also to a Reduction in the metabolic clearance of DGX by ITZ.

Effect of quinidine on the inotropic effect of digoxin in isolated cat or guinea-pig papillary muscle

Data suggest that an interaction between quinidine and digoxin exists in isolated cat papillary muscle, but this interaction is not apparent in guinea-pig muscle, therefore, when studying the interaction between these two drugs, the choice of the animal species used may be important.

Assessment of Pharmacokinetic and Pharmacodynamic Drug Interactions between Nefazodone and Digoxin in Healthy Male Volunteers

Because digoxin has a narrow therapeutic index, monitoring of plasma digoxin levels and appropriate adjustment of dosage are recommended when nefazodone and digoxin are administered concurrently.

Application of permeability-limited physiologically-based pharmacokinetic models: part II - prediction of P-glycoprotein mediated drug-drug interactions with digoxin.

This study demonstrates the application of permeability-limited models of absorption and distribution within a PBPK framework together with relevant in vitro data on transporters to assess the clinical impact of modulated P-gp-mediated efflux by drugs in development.

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