Effect of quetiapine and norquetiapine on anxiety and depression in major psychoses using a pharmacokinetic approach: a prospective observational study.

@article{Altamura2012EffectOQ,
  title={Effect of quetiapine and norquetiapine on anxiety and depression in major psychoses using a pharmacokinetic approach: a prospective observational study.},
  author={Alfredo Carlo Altamura and Donatella Moliterno and Silvia Paletta and Massimiliano Buoli and Bernardo Dell'osso and Massimo Carlo Mauri and Silvio R Bareggi},
  journal={Clinical drug investigation},
  year={2012},
  volume={32 3},
  pages={213-9}
}
BACKGROUND Quetiapine apparently differs from other antipsychotic drugs in terms of its antidepressant activity and efficacy in bipolar depression. The mechanism of this activity is unknown although it may be mediated by its metabolite N-desalkylquetiapine (norquetiapine). OBJECTIVE The aim of the study was to analyse the relationships between quetiapine… CONTINUE READING