Effect of pyrimethamine and sulphadoxine on human lymphocyte proliferation.

  title={Effect of pyrimethamine and sulphadoxine on human lymphocyte proliferation.},
  author={I B Christian Bygbjerg and N Joey Odum and Thor G. Theander},
  journal={Transactions of the Royal Society of Tropical Medicine and Hygiene},
  volume={80 2},
The in vitro effect of pyrimethamine (PYR) on human blood mononuclear cells stimulated with phytohaemagglutinin (PHA), pokeweed mitogen (PWM) and purified protein derivative of tuberculin (PPD) was studied by 14C-thymidine incorporation, by cell counting and by total DNA estimation. PYR in concentrations 10 times higher than serum values obtained in clinical practice inhibited lymphocyte proliferation irreversibly. PYR in concentrations corresponding to clinical practice quickly and… CONTINUE READING