Effect of pyridoxine deficiency on aromatic L-amino acid decarboxylase in adult rat brain

@article{Siow1985EffectOP,
  title={Effect of pyridoxine deficiency on aromatic L-amino acid decarboxylase in adult rat brain},
  author={Yaw Chris Siow and Krishnamurti Dakshinamurti},
  journal={Experimental Brain Research},
  year={1985},
  volume={59},
  pages={575-581}
}
We have investigated the effect of pyridoxine deficiency on aromatic L-amino acid decarboxylase (AADC) using both dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5HTP) as substrates in the rat brain. The activity ratios of DOPA decarboxylase/5HTP decarboxylase measured under optimal substrate and cofactor concentrations were different in the cerebellum, cerebral cortex, corpus striatum and hypothalamus of the normal rat. In pyridoxine deficiency, there were no parallel decreases in DOPA… CONTINUE READING

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