Effect of pyridoxal 5-phosphate on carbidopa and decarboxylation of levodopa.

  title={Effect of pyridoxal 5-phosphate on carbidopa and decarboxylation of levodopa.},
  author={V D Das Gupta and A. K. Gupta},
  journal={Journal of pharmaceutical sciences},
  volume={69 10},
To study the interaction between enzymes and coenzymes and carbidopa and levodopa, a paired-ion high-pressure liquid chromatographic method was developed to separate carbidopa, dopamine, levodopa, and pyridoxal 5-phosphate. Carbidopa strongly reacted with pyridoxal 5-phosphate, contrary to a previous report. Tyrosine decarboxylase and tyrosine decarboxylase apoenzyme had some activity against levodopa, which could be increased by adding pyridoxal 5-phosphate to the mixture. This activity was… 

Emerging Role of l-Dopa Decarboxylase in Flaviviridae Virus Infections

Data reveal a novel relationship between DDC and Flaviviridae replication cycle and the role of PI3K in this process, and provide compelling evidence for the involvement of DDC in viral infections.

Protein‐Templated Fragment Ligations—From Molecular Recognition to Drug Discovery

The biophysical basis of reversible and irreversible fragment ligations is discussed and an overview of the available methods to detect protein‐templated ligation products are given.

Proteintemplat‐gesteuerte Fragmentligationen – von der molekularen Erkennung zur Wirkstofffindung

Dieser Aufsatz diskutiert die biophysikalischen Grundlagen der reversiblen and irreversiblen Fragmentligationen and gibt einen Überblick über die Methoden, mit denen die durch das Proteintemplat gebildeten Ligationsprodukte detektiert werden können.


  • Protein Biosynthesis Interference in Disease
  • 2021



Applications of paired ion high-pressure liquid chromatography to catecholamines and phenylephrine.

Paired ion high-pressure liquid chromatography was useful for separating intact catecholamines (epinephrine, isoproterenol, levodopa, and methyldopa) and phenylephrine from some of their


The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.