Effect of pyridoxal 5-phosphate on carbidopa and decarboxylation of levodopa.

@article{DasGupta1980EffectOP,
  title={Effect of pyridoxal 5-phosphate on carbidopa and decarboxylation of levodopa.},
  author={V D Das Gupta and A. K. Gupta},
  journal={Journal of pharmaceutical sciences},
  year={1980},
  volume={69 10},
  pages={
          1145-8
        }
}
To study the interaction between enzymes and coenzymes and carbidopa and levodopa, a paired-ion high-pressure liquid chromatographic method was developed to separate carbidopa, dopamine, levodopa, and pyridoxal 5-phosphate. Carbidopa strongly reacted with pyridoxal 5-phosphate, contrary to a previous report. Tyrosine decarboxylase and tyrosine decarboxylase apoenzyme had some activity against levodopa, which could be increased by adding pyridoxal 5-phosphate to the mixture. This activity was… 
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Inhibition of dopa decarboxylase by the hydrazino analog of α-methyldopa

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Paired ion high-pressure liquid chromatography was useful for separating intact catecholamines (epinephrine, isoproterenol, levodopa, and methyldopa) and phenylephrine from some of their…

THE UNITED STATES PHARMACOPEIA.

The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.