Effect of pyridoxal 5-phosphate on carbidopa and decarboxylation of levodopa.

@article{DasGupta1980EffectOP,
  title={Effect of pyridoxal 5-phosphate on carbidopa and decarboxylation of levodopa.},
  author={V D Das Gupta and A. K. Gupta},
  journal={Journal of pharmaceutical sciences},
  year={1980},
  volume={69 10},
  pages={
          1145-8
        }
}
To study the interaction between enzymes and coenzymes and carbidopa and levodopa, a paired-ion high-pressure liquid chromatographic method was developed to separate carbidopa, dopamine, levodopa, and pyridoxal 5-phosphate. Carbidopa strongly reacted with pyridoxal 5-phosphate, contrary to a previous report. Tyrosine decarboxylase and tyrosine decarboxylase apoenzyme had some activity against levodopa, which could be increased by adding pyridoxal 5-phosphate to the mixture. This activity was… 
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References

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Paired ion high-pressure liquid chromatography was useful for separating intact catecholamines (epinephrine, isoproterenol, levodopa, and methyldopa) and phenylephrine from some of their…

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The Pharmacopeia was called into being by physicians in 1820, and in 1850 pharmacists were admitted to the convention; since then physicians have gradually relinquished control to pharmacists, and to-day the authors are confronted with an anomalous condition.