Effect of pyrazinamide on nicotinamide adenine dinucleotide glycohydrolase of tuberculous host.

@article{Toida1973EffectOP,
  title={Effect of pyrazinamide on nicotinamide adenine dinucleotide glycohydrolase of tuberculous host.},
  author={I. Toida},
  journal={The American review of respiratory disease},
  year={1973},
  volume={107 4},
  pages={
          648-55
        }
}
  • I. Toida
  • Published 1 April 1973
  • Chemistry, Medicine
  • The American review of respiratory disease
Nicotinamide adenine dinucleotide glycohydrolase (NADase) activity of mice liver was increased after infection with strains of tubercle bacilli either susceptible or resistant to pyrazinamide. Pyrazinamide and nicotinamide, as well as isoniazid, suppressed the increase of NADase associated with tuberculous infection with the bacilli susceptible to these drugs. Pyrazinamide and nicotinamide did not influence the increased NADase produced by bacilli resistant to these drugs. the effects of… 

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The resistance or susceptibility of tubercle bacilli to pyrazinamide is focused on as one approach to the study of the sterilization phenomenon of M. tuberculosis.
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The observations suggest that the ability of pyrazinamide-containing chemotherapies to bring about the disappearance of a tubercle bacilli is closely related to the occurrence of some alteration in the bacillus, essential for maximal pyraz inamide action, in response to environmental influences, including other antituberculous drugs present in the environment.
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