Effect of pyran copolymer on activation of murine macrophages: evidence for incomplete activation by use of functional markers.

@article{Adams1983EffectOP,
  title={Effect of pyran copolymer on activation of murine macrophages: evidence for incomplete activation by use of functional markers.},
  author={D. O. Adams and W. J. Johnson and Pamela A. Marino and Jack H. Dean},
  journal={Cancer research},
  year={1983},
  volume={43 8},
  pages={3633-7}
}
The degree of activation of peritoneal macrophages elicited by pyran copolymer (MVE-2) was studied in C57BL/6J mice. When cytotoxicity was examined under endotoxin-free culture conditions, the pyran-elicited macrophages could not complete cytolysis of tumor target cells. The macrophages, however, completed cytolysis when pulsed with endotoxin. These results were obtained when either the interval between injection of the pyran copolymer and harvest of the macrophage or the dose of pyran was… CONTINUE READING