Effect of prucalopride, a new enterokinetic agent, on gastrointestinal transit and anorectal function in healthy volunteers.

@article{Poen1999EffectOP,
  title={Effect of prucalopride, a new enterokinetic agent, on gastrointestinal transit and anorectal function in healthy volunteers.},
  author={Alexander C. Poen and Richelle J. F. Felt-Bersma and P A van Dongen and Stephan G. M. Meuwissen},
  journal={Alimentary pharmacology & therapeutics},
  year={1999},
  volume={13 11},
  pages={1493-7}
}
BACKGROUND Prucalopride (PR) is a novel 5-HT4 agonist enterokinetic compound. AIM To evaluate its effect on bowel function, gut transit and anorectal function in healthy volunteers using a double-blind, placebo-controlled crossover study. METHODS Twenty-four healthy volunteers (12 men, 12 women, mean age 25 years, range 20-53 years) were randomly assigned to 1 mg/placebo or 2 mg/placebo (PL). The trial consisted of five consecutive 1 week periods: no drug treatment, PR treatment or PL… CONTINUE READING
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