Effect of prototypical inducing agents on P-glycoprotein and CYP3A expression in mouse tissues.

@article{Matheny2004EffectOP,
  title={Effect of prototypical inducing agents on P-glycoprotein and CYP3A expression in mouse tissues.},
  author={Christopher J Matheny and Rabia Y. Ali and Xiaodong Yang and Gary M. Pollack},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2004},
  volume={32 9},
  pages={1008-14}
}
P-glycoprotein (P-gp) and CYP3A have considerable overlap in inducers in vitro. Characterizing P-gp induction in vivo and potential coregulation with CYP3A are important goals for predicting drug interactions. This study examined P-gp expression in mouse tissues and potential coinduction with CYP3A following oral treatment with 1 of 7 prototypical inducing agents for 5 days. P-gp expression in brain or liver was not induced by any treatment as determined by Western blot, whereas dexamethasone… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Similar Papers

Loading similar papers…