Effect of proton beam on blood vessel formation in early developing zebrafish (Danio rerio) embryos.

@article{Jang2008EffectOP,
  title={Effect of proton beam on blood vessel formation in early developing zebrafish (Danio rerio) embryos.},
  author={Gun Hyuk Jang and J Ha and Tae-lin Huh and You Mie Lee},
  journal={Archives of pharmacal research},
  year={2008},
  volume={31 6},
  pages={779-85}
}
Proton beam therapy can kill tumor cells while saving normal cells because of its specific energy delivery properties and so is used to various tumor patients. However, the effect of proton beam on angiogenesis in the development of blood vessels has not been determined. Here we used the zebrafish model to determine in vivo whether proton beam inhibits angiogenesis. Flk-1-GFP transgenic embryos irradiated with protons (35 MeV, spread out Bragg peak, SOBP) demonstrated a marked inhibition of… CONTINUE READING