Effect of protein kinase inhibitors on the invasion process of macrophages by Trypanosoma cruzi.

Abstract

The interaction of Trypanosoma cruzi with different vertebrate cells involves two distinct steps, attachment and internalization. Genistein and staurosporine, drugs which inhibit protein kinases, specially tyrosine kinase, are able to block the infection of macrophages by T. cruzi, suggesting that protein phosphorylation is a key event on this process. 

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