Effect of protein kinase inhibitors on the growth, morphology, and infectivity of Leishmania promastigotes

@article{Becker1997EffectOP,
  title={Effect of protein kinase inhibitors on the growth, morphology, and infectivity of Leishmania promastigotes},
  author={Stephan Becker and Charles L Jaffe},
  journal={Parasitology Research},
  year={1997},
  volume={83},
  pages={273-280}
}
The effect of two protein kinase inhibitors, staurosporine and H-7, on the growth, morphology and infectivity of Leishmania major and Leishmania amazonensis promastigotes was examined. Incubation with H-7 (600 μM) for up to one hour had no effect on parasite growth, morphology or infectivity. Staurosporine, however, was cytotoxic for promastigotes and incubation for 1, 5 or 15 minutes with 10 μM inhibitor killed 19, 34 and 59 %, respectively, of the parasites. Longer incubations, up to one hour… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Effects of hypoxia, acute osmotic stress, and protein kinase inhibitors on the intermediary metabolism of Leishmania

  • JJ Blum
  • J Eukaryot Microbiol
  • 1994
Highly Influential
4 Excerpts

Protein Kinase C inhibitor H-7 alters the actin cytoskeleton of cultured cells

  • GB Birrell, KK Hedberg, DL Habilston, OH Griffith
  • J Cell Physiol
  • 1989
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…