Effect of protein kinase C inhibitors on endothelin- and vasopressin-induced constriction of the rat basilar artery.

@article{Murray1992EffectOP,
  title={Effect of protein kinase C inhibitors on endothelin- and vasopressin-induced constriction of the rat basilar artery.},
  author={Mary Ann Murray and Frank M. Faraci and Donald D. Heistad},
  journal={The American journal of physiology},
  year={1992},
  volume={263 6 Pt 2},
  pages={H1643-9}
}
The goal of this study was to determine whether inhibitors of protein kinase C (PKC) attenuate constrictor responses of the basilar artery in vivo to endothelin and arginine vasopressin. In anesthetized rats, the diameter of basilar arteries was measured through a cranial window [control diameter 218 +/- 3 (SE) microns]. Vessel diameter was measured during topical application of agonists and antagonists. Sphingosine (10(-6) M), a PKC inhibitor that binds to the regulatory site of PKC… CONTINUE READING

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