Effect of protein kinase C and insulin on Na+/H+ exchange in red blood cells of essential hypertensives

Abstract

The kinetic properties of sodium-proton exchange are abnormal in human red blood cells of hypertensive patients and it has been demonstrated that the transport protein undergoes post-translational modifications able to affect its kinetic properties. Protein kinase C (PKC) activation decreases the affinity constant for intracellular protons while insulin… (More)
DOI: 10.1038/sj.jhh.1000804

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