Effect of protein kinase-C activation on the Mg(2+)-sensitivity of cloned NMDA receptors.

@article{Wagner1996EffectOP,
  title={Effect of protein kinase-C activation on the Mg(2+)-sensitivity of cloned NMDA receptors.},
  author={David A. Wagner and John P. Leonard},
  journal={Neuropharmacology},
  year={1996},
  volume={35 1},
  pages={29-36}
}
The mechanisms responsible for protein kinase-c (PKC) mediated potentiation of NMDA receptors are poorly understood. One hypothesis is that PKC-activation reduces the receptor's characteristic voltage-dependent Mg(2+)-blockade. Experiments performed on Xenopus oocytes expressing cloned NMDA receptors demonstrated that PKC-activation induced no change in the sensitivity of zeta 1/epsilon 3 and zeta 1/epsilon 4 receptors to Mg(2+)-blockade and, even though PKC-activation did induce a small shift… CONTINUE READING

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