Effect of protein binding on testosterone extraction by human cirrhotic liver: evidence for a dissociation-limited uptake.

@article{Guchot1989EffectOP,
  title={Effect of protein binding on testosterone extraction by human cirrhotic liver: evidence for a dissociation-limited uptake.},
  author={J{\'e}r{\^o}me Gu{\'e}chot and Sylvain Loric and Michel Vaubourdolle and Yves Chr{\'e}tien and Jacqueline Giboudeau and Ren{\'e}e Eug{\'e}nie Poupon},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1989},
  volume={69 1},
  pages={200-3}
}
Testosterone (T) is a protein-bound substance, the hepatic extraction of which largely exceeds the free plasma fraction. In this study we attempted to determine if the dissociation of T from plasma proteins is the limiting factor for testosterone hepatic uptake in patients with cirrhosis. For this purpose we measured the hepatic uptake of T and the… CONTINUE READING