Effect of prostaglandin endoperoxide analogue on canine renal function, hemodynamics and renin release.

@article{Gerber1979EffectOP,
  title={Effect of prostaglandin endoperoxide analogue on canine renal function, hemodynamics and renin release.},
  author={John G. Gerber and Elisabeth Ellis and J Hollified and Alan S. Nies},
  journal={European journal of pharmacology},
  year={1979},
  volume={53 3},
  pages={239-46}
}
We studied the effect of a stable, cyclic ether analogue of prostaglandin endoperoxide (EPA) on canine renal function, hemodynamics, and renin release. Infusion of EPA into one renal artery decreased renal blood flow in a dose dependent manner. At a dose of 10(-7) g/kg/min the renal blood flow decreased from a baseline of 384 to 267 ml/min/100 g. This flow… CONTINUE READING