Effect of prostacyclin on platelets, polymorphonuclear cells, and heterotypic cell aggregation during hemofiltration.

@article{KozekLangenecker2003EffectOP,
  title={Effect of prostacyclin on platelets, polymorphonuclear cells, and heterotypic cell aggregation during hemofiltration.},
  author={Sibylle A. Kozek-Langenecker and Christian K. Spiss and Andrea Michalek-Sauberer and Michael Felfernig and Michael Zimpfer},
  journal={Critical care medicine},
  year={2003},
  volume={31 3},
  pages={864-8}
}
OBJECTIVES Hemodialysis activates both platelets and leukocytes, which play a role in the development of multiple organ dysfunctions in critically ill patients. Prostacyclin inhibits both cell types. To examine the hypothesis that prostacyclin prevents cellular activation during clinical hemofiltration, we investigated the expression of activation markers on platelets and leukocytes using whole blood flow cytometry. DESIGN Prospective, randomized, double-blind, controlled trial. SETTING… CONTINUE READING

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