Effect of propranolol on endotoxin-induced pyrogenesis in newborn and adult guinea pigs.

@article{Blatteis1976EffectOP,
  title={Effect of propranolol on endotoxin-induced pyrogenesis in newborn and adult guinea pigs.},
  author={Clark M. Blatteis},
  journal={Journal of applied physiology},
  year={1976},
  volume={40 1},
  pages={35-9}
}
Previous studied have shown that nonshivering thermogenesis (NST) is the prevailing mechanism of fever production in both newborn (during the first 2-3 wk of life) and adult cold-acclimated guinea pigs. This study was undertaken to determine whether this process may be mediated by noradrenergic sympathetics. The temperatures in the interscapular brown fat pad (Tbat) and the colon (Tre), the rate of oxygen consumption (VO2), and shivering activity were measured continuously for 5 h at 27 degrees… CONTINUE READING
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