Effect of propofol on the levels of neurotransmitters in normal human brain: A magnetic resonance spectroscopy study

@article{Zhang2009EffectOP,
  title={Effect of propofol on the levels of neurotransmitters in normal human brain: A magnetic resonance spectroscopy study},
  author={Hui Zhang and Wei Wang and Wei Gao and Ya-li Ge and Jinsong Zhang and Shengxi Wu and Lixian Xu},
  journal={Neuroscience Letters},
  year={2009},
  volume={467},
  pages={247-251}
}

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References

SHOWING 1-10 OF 25 REFERENCES
Neural Mechanism of Propofol Anesthesia in Severe Depression: A Positron Emission Tomographic Study
Background The precise neural mechanisms of propofol anesthesia in humans are still unknown. The authors examined the acute effects of propofol on regional cerebral blood flow (rCBF) using positron
Effects of Intravenous Anesthetic Agents on Glutamate Release: A Role for GABAA Receptor–Mediated Inhibition
TLDR
The data indicate that thiopental, propofol, and ketamine inhibit K+-evoked glutamate release from rat cerebrocortical slices, revealing a subtle interplay between GABA-releasing (GABAergic) and glutamatergic transmission in anesthetic action.
Propofol and Isoflurane Enhancement of Tonic Gamma-Aminobutyric Acid Type A Current in Cardiac Vagal Neurons in the Nucleus Ambiguus
  • Xin Wang
  • Biology, Medicine
    Anesthesia and analgesia
  • 2009
TLDR
It is demonstrated that the general anesthetics propofol and isoflurane enhance both phasic and tonic GABAA receptor-mediated inhibition of CVNs.
Widespread Inhibition of Sodium Channel–dependent Glutamate Release from Isolated Nerve Terminals by Isoflurane and Propofol
TLDR
These findings are consistent with a greater sensitivity to anesthetics of presynaptic Na+ channels than of Ca2+ channels coupled to glutamate release and are not mediated by potentiation of &ggr;-aminobutyric acid type A receptors, though additional mechanisms may be involved.
Antenatal proton MR spectroscopy of the human brain in vivo
TLDR
Under proper care for the methodological aspects, antenatal 1H MRS clearly has the potential to evolve into a clinical tool for assessing a number of key metabolites in the human fetal brain in utero.
Relationship between depth of anesthesia and effect-site concentration of propofol during induction with the target-controlled infusion technique in elderly patients.
TLDR
A two-stepTCI technique seems to be a more suitable method of anesthesia induction in elderly patients compared with the no-stepwise TCI technique and three-step TCI techniques.
Effects of Isoflurane and Propofol on Glutamate and GABA Transporters in Isolated Cortical Nerve Terminals
TLDR
Findings suggest that isoflurane and propofol at clinical concentrations do not affect excitatory glutamatergic transmission or inhibitory GABAergic transmission directly via effects on their presynaptic neuronal transporters.
Propofol Increases Presynaptic Inhibition of Ia Afferents in the Intact Human Spinal Cord
TLDR
Strong evidence form neurophysiologic studies indicates that the findings of this study are most likely explained by a specific presynaptic effect of propofol, mediated by the GABA type A receptors.
Why do women wake up faster than men from propofol anaesthesia?
TLDR
Gender differences in pharmacokinetics could explain the faster emergence for female patients after prop ofol anaesthesia, and gender differences in propofol sensitivity may also be present.
Volatile Anesthetic Effects on Glutamate versus GABA Release from Isolated Rat Cortical Nerve Terminals: Basal Release
TLDR
All three volatile anesthetics at clinical concentrations consistently reduced the ratio of basal glutamate to GABA release, which may contribute to the net depression of glutamatergic excitation and potentiation of GABAergic inhibition characteristic of general anesthesia.
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