Effect of propofol on the levels of neurotransmitters in normal human brain: A magnetic resonance spectroscopy study

@article{Zhang2009EffectOP,
  title={Effect of propofol on the levels of neurotransmitters in normal human brain: A magnetic resonance spectroscopy study},
  author={Hui Zhang and Wei Wang and Wei Gao and Ya-li Ge and Jinsong Zhang and Shengxi Wu and Lixian Xu},
  journal={Neuroscience Letters},
  year={2009},
  volume={467},
  pages={247-251}
}
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39 Citations
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Background Citations
15
Methods Citations
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Results Citations
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39 Citations

The Action Sites of Propofol in the Normal Human Brain Revealed by Functional Magnetic Resonance Imaging
TLDR
Functional magnetic resonance imaging shows that there is most significant inhibition in hypothalamus, frontal lobe, and temporal in propofol anesthesia and moderate inhibition in thalamus, which suggests these brain regions might be the targets of prop ofol anesthesia in human brain.
Effects of propofol on sleep architecture and sleep–wake systems in rats
[GAT-1 and GAD65 mRNA expressions in different brain regions in dogs at brain propofol uptake equilibrium].
TLDR
GAT-1 mRNA in the hypothalamus and hippocampus and GAD65 RNA in the dorsal thalamus are upregulated when propofol uptake reaches an equilibrium in the brain of dogs.
Alterations In Regional Cerebral Blood Flow With Propofol Anesthesia Compared With Sevoflurane
TLDR
It is hypothesize that sevoflurane and propofol produce spatially non-uniform changes in rCBF, with significant decreases in the thalamus and prefrontal cortex, and the difference was calculated (δCBF).
Propofol protects against impairment of learning-memory and imbalance of hippocampal Glu/GABA induced by electroconvulsive shock in depressed rats
TLDR
The data suggest that propofol alleviated ECS-induced learning-memory impairment without interfering with the antidepressant efficacy of ECS, possibly by inhibiting excessive expression of GAD65 and maintaining the balance between glutamatergic and GABAergic amino acids neurotransmitters in the hippocampus.
Effect of Propofol on the Release of [3H] Acetylcholine from Rat Hippocampal Synaptosomes
TLDR
It seems that propofol decreased the release of ACh in the rat hippocampus by interfering with Na+ channels and therelease of Ca2+ from internal stores.
Psychostimulant drug effects on glutamate, Glx, and creatine in the anterior cingulate cortex and subjective response in healthy humans
TLDR
It is concluded that d-amphetamine increased the concentration of glutamate, Glx, and tCr in the dACC in male and female volunteers 21/2 hours after drug consumption, the first experimental evidence that specific psychostimulants increase the level of glutamatergic compounds in the human brain.
Propofol can Protect Against the Impairment of Learning-memory Induced by Electroconvulsive Shock via Tau Protein Hyperphosphorylation in Depressed Rats.
  • Wanping LiuChao-feng Liu
  • Biology, Psychology
    Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
  • 2015
Effects of propofol and pentobarbital on calcium concentration in presynaptic boutons on a rat hippocampal neuron
TLDR
Propofol and pentobarbital may affect neurotransmitter release from the excitatory presynaptic nerve terminals due to inhibition of increase in [Ca2+]pre, and as a large majority of exciteatory synapses are located on dendritic spines, these agents may affect Ca2+ mobilization in the exciteful presyaptic boutons.
Regional variations and age-related changes detected with magnetic resonance spectroscopy in the brain of healthy dogs.
TLDR
Investigation of age-related and regional differences in estimated metabolite concentrations in the brain of healthy dogs by means of magnetic resonance spectroscopy found the choline-to-creatine ratio was significantly higher in young dogs, compared with other age groups.
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References

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Background The precise neural mechanisms of propofol anesthesia in humans are still unknown. The authors examined the acute effects of propofol on regional cerebral blood flow (rCBF) using positron…
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TLDR
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TLDR
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TLDR
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TLDR
Gender differences in pharmacokinetics could explain the faster emergence for female patients after prop ofol anaesthesia, and gender differences in propofol sensitivity may also be present.
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TLDR
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