Corpus ID: 38339017

Effect of propentofylline on hypoxic-ischaemic brain damage in newborn rat.

@article{Xia2004EffectOP,
  title={Effect of propentofylline on hypoxic-ischaemic brain damage in newborn rat.},
  author={X. Xia and H. Sameshima and A. Ota and Y. Xia and T. Ikenoue and K. Toshimori and X. Huang},
  journal={Chinese medical journal},
  year={2004},
  volume={117 8},
  pages={
          1190-4
        }
}
BACKGROUND Studies showed that propentofylline enhances the action of adenosine and protects hippocampal neuronal damage against transient global cerebral ischaemia. Our study was to investigate the effect of propentofylline on hypoxic-ischaemic brain damage in neonatal rat. METHODS Seven-day-old Wistar rats were subjected to unilateral common carotid artery ligation and hypoxia in oxygen 8 kPa for two hours at 37 degrees C. Propentofylline (10 mg/kg) was administered intraperitoneally one… Expand
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