Effect of propentofylline on hippocampal brain energy state and amyloid precursor protein concentration in a rat model of cerebral hypoperfusion

@article{Plaschke1998EffectOP,
  title={Effect of propentofylline on hippocampal brain energy state and amyloid precursor protein concentration in a rat model of cerebral hypoperfusion},
  author={K. Plaschke and E. Martin and H. Bardenheuer},
  journal={Journal of Neural Transmission},
  year={1998},
  volume={105},
  pages={1065-1077}
}
Summary. An animal model of graded cerebral hypoperfusion achieved by way of 2- and 4-brain vessel occlusion (vo) was used to test the effect of chronic propentofylline (PPF) administration on hippocampal energy state and amyloid precursor protein (APP) concentration. For this purpose, forty adult rats were subjected to stepwise and permanent 2 vo and 4 vo and PPF in a dose of 25 mg/day per kilogram body weight was continuously administered intraperitoneally for 1 week or 3 weeks, respectively… Expand
Amyloid precursor protein (APP) and its derivatives change after cellular energy depletion. An in vitro-study
The Involvement of Canonical Wnt Signaling in Memory Impairment Induced by Chronic Cerebral Hypoperfusion in Mice
...
1
2
...

References

SHOWING 1-10 OF 64 REFERENCES
Effect of propentofylline on cerebral metabolism of rats
Effect of Propentofylline on Regional Cerebral Glucose Metabolism in Acute Ischemic Stroke
Antiischemic effects of propentofylline (HWA 285) against focal cerebral infarction in rats
Effect of propentofylline on the GABA system of a rat brain
Ischemia and the aging brain. Studies on glucose and energy metabolism in rat cerebral cortex
Glial Expression of the β-Amyloid Precursor Protein (APP) in Global Ischemia
...
1
2
3
4
5
...