Effect of promoter methylation of multidrug resistance 1 (MDR1) gene in gastric carcinogenesis.


BACKGROUND The altered expression of multidrug resistance 1 (MDR1) contributes to various types of carcinogenesis and their disease progression. Hypermethylation of CpG islands located in the promoter regions is involved in gene silencing at the transcriptional level. The methylation status of MDR1 gene promoter was investigated in gastric cancer in… (More)

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