Effect of prolonged mechanical ventilation on diaphragm muscle mitochondria in piglets.

@article{Fredriksson2005EffectOP,
  title={Effect of prolonged mechanical ventilation on diaphragm muscle mitochondria in piglets.},
  author={Katarina Fredriksson and Peter J. Radell and L. Ingvar Eriksson and Kjell Hultenby and Olav Rooyackers},
  journal={Acta anaesthesiologica Scandinavica},
  year={2005},
  volume={49 8},
  pages={
          1101-7
        }
}
BACKGROUND Respiratory muscle weakness is a common problem in the intensive care unit and could be involved in difficulties in weaning from the ventilator after prolonged mechanical ventilation. Animal models have shown that mechanical ventilation itself impairs diaphragm muscle function. In this study we investigated whether diaphragm contractile impairment caused by mechanical ventilation and immobilization in piglets is associated with a derangement in diaphragm mitochondria. METHODS Seven… CONTINUE READING
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Ventilator-Induced Diaphragm Dysfunction ( Review )

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