Effect of prolonged insulin treatment on blunted plasma catecholamine and glucagon increase during insulin hypoglycemia in streptozotocin diabetic rats.

@article{Patel1983EffectOP,
  title={Effect of prolonged insulin treatment on blunted plasma catecholamine and glucagon increase during insulin hypoglycemia in streptozotocin diabetic rats.},
  author={Dr. Ganesh K. Patel},
  journal={Metabolism: clinical and experimental},
  year={1983},
  volume={32 4},
  pages={377-82}
}
The role of prolonged insulin treatment of diabetic rats on the lack of glucagon and catecholamine increases in response to insulin-hypoglycemia was investigated. Streptozotocin diabetic rats were maintained in a normoglycemic state for a long period by intraperitoneal constant infusion of insulin with the Alzet osmotic minipumps. Hyperglucagonemia observed in diabetic rats was normalized with insulin treatment. However, the blunted response of glucagon during insulin-hypoglycemia was not… CONTINUE READING