Effect of proline analogs on oxygen toxicity-induced pulmonary fibrosis in the rat.

Abstract

Proline analogs inhibit collagen biosynthesis and prevent accumulation of collagen in tissues. The antifibrotic effects of three proline analogs, cis-hydroxyproline, L-azetidine-2-carboxylic acid, and L-3,4-dehydroproline, were compared in a rat oxygen toxicity model. The specificity of these agents for collagen was examined by measuring their effects on… (More)

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@article{Riley1984EffectOP, title={Effect of proline analogs on oxygen toxicity-induced pulmonary fibrosis in the rat.}, author={D. J. Riley and Jennifer Kerr and S. Y. Yu}, journal={Toxicology and applied pharmacology}, year={1984}, volume={75 3}, pages={554-60} }