Effect of progestin on the ovarian epithelium of macaques: cancer prevention through apoptosis?

@article{Rodriguez1998EffectOP,
  title={Effect of progestin on the ovarian epithelium of macaques: cancer prevention through apoptosis?},
  author={Gustavo C. Rodriguez and David K. Walmer and Mark Maienschein Cline and H Krigman and Bruce A. Lessey and Regina S. Whitaker and Richard N. Dodge and Claude L. Hughes},
  journal={Journal of the Society for Gynecologic Investigation},
  year={1998},
  volume={5 5},
  pages={271-6}
}
OBJECTIVE The apoptosis pathway is a vital mechanism in vivo that functions to eradicate genetically damaged cells prone to malignancy. The purpose of this study was to determine whether oral contraceptives, which confer significant protection against subsequent epithelial ovarian cancer, induce apoptosis in the ovarian epithelium. METHODS Female cynomolgus macaques (N = 75) were randomized to receive a diet for 35 months containing either no hormones, the oral contraceptive Triphasil (Wyeth… CONTINUE READING
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