Effect of probenecid on riboflavin absorption and excretion in man.

@article{Jusko1967EffectOP,
  title={Effect of probenecid on riboflavin absorption and excretion in man.},
  author={William J. Jusko and Gerhard Levy},
  journal={Journal of pharmaceutical sciences},
  year={1967},
  volume={56 9},
  pages={
          1145-9
        }
}
  • W. Jusko, G. Levy
  • Published 1 September 1967
  • Biology
  • Journal of pharmaceutical sciences
An oral dose of probenecid given 1 hr. prior to oral administration of riboflavin or riboflavin-5′-phosphate (FMN) to normal humans produced a marked decrease in the excretion rate of the vitamin during the early excretion phase but had no significant effect during the later (post-absorptive) phase. Oral administration of probenecid prior to intramuscular injection of FMN increased the apparent “half-life” of the initial rapid phase of riboflavin excretion. The urinary recovery of riboflavin… 

Effect of probenecid on renal clearance of riboflavin in man.

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There is indication that the interaction between FR and albumin is nonionic, but that electrostatic forces contribute appreciably to the binding of FMN to albumin.

Flavin levels in the rat retina.

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Analysis of flavins in ocular tissues of the rabbit.

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The relative contribution of riboflavin, FMN, and FAD to the total flavin pool was markedly different in the various tissues of the eye, and the proportion of tissue flavins present as rib oflavin decreased from anterior to posterior.

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Semi-mechanistic kidney model incorporating physiologically-relevant fluid reabsorption and transporter-mediated renal reabsorption: pharmacokinetics of γ-hydroxybutyric acid and l-lactate in rats

  • R. DaveM. Morris
  • Biology, Medicine
    Journal of Pharmacokinetics and Pharmacodynamics
  • 2015
TLDR
A semi-mechanistic kidney model is developed that can be used to evaluate transporter-mediated active renal reabsorption of drugs by the kidney and the pharmacokinetics of l-lactate.

References

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Absorption, metabolism, and excretion of riboflavin-5'-phosphate in man.

TLDR
Evidence is presented which indicates that riboflavin-5′-phosphate (FMN) is absorbed from the gastrointestinal tract of man by specialized transport rather than by passive diffusion, suggesting that the vitamin is subject to enterohepatic cycling.

Factors affecting the absorption of riboflavin in man.

TLDR
The urinary recovery of rib oflavin as a function of dose after oral administration to fasted normal humans shows that the process responsible for the absorption of this vitamin is saturable, and the site specificity and saturability of riboflavin absorption suggest that the vitamin is absorbed by specialized transport rather than by passive diffusion.

The physiological disposition of probenecid, including renal clearance, in man, studied by an improved method for its estimation in biological material.

TLDR
Probenecid was found to be rapidly and fairly completely absorbed from the human gastrointestinal tract and the half-life studies indicate that the drug must be transformed to unknown metabolites or conjugates.

THE EFFECT OF PROBENECID (P-(DI-N-PROPYLSULFAMYL)-BENZOIC ACID) ON THE SPONTANEOUS RENAL EXCRETION OF BIOLOGICALLY ACTIVE METABOLITES OF THIAMINE, RIBOFLAVIN AND PANTOTHENIC ACID.

A study has been made of the effect of the tubular inhibitor Probenecid on the spontaneous renal excretion of microbiologically determinable thiamine, riboflavin and pantothenic acid in eight rabbits

Apparent renal tubular secretion of riboflavin in man.