Effect of probenecid on cerebrospinal fluid concentrations of penicillin and cephalosporin derivatives.

@article{Dacey1974EffectOP,
  title={Effect of probenecid on cerebrospinal fluid concentrations of penicillin and cephalosporin derivatives.},
  author={Ralph Dacey and M. A. J. van de Sande},
  journal={Antimicrobial agents and chemotherapy},
  year={1974},
  volume={6 4},
  pages={437-41}
}
Probenecid may elevate the cerebrospinal fluid (CSF) concentration of penicillin G by inhibiting the excretion of organic acids from CSF. We have studied this phenomenon with various penicillin and cephalosporin derivatives. Penicillin concentrations were determined in rabbits under steady-state conditions before and after intravenous probenecid administration. With both low-dose and high-dose probenecid, CSF penicillin levels increased two to three times as did CSF concentration as a… CONTINUE READING