Effect of probenecid on cerebrospinal fluid concentrations of penicillin and cephalosporin derivatives.

Abstract

Probenecid may elevate the cerebrospinal fluid (CSF) concentration of penicillin G by inhibiting the excretion of organic acids from CSF. We have studied this phenomenon with various penicillin and cephalosporin derivatives. Penicillin concentrations were determined in rabbits under steady-state conditions before and after intravenous probenecid… (More)

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@article{Dacey1974EffectOP, title={Effect of probenecid on cerebrospinal fluid concentrations of penicillin and cephalosporin derivatives.}, author={Ralph Dacey and Merle A. Sande}, journal={Antimicrobial agents and chemotherapy}, year={1974}, volume={6 4}, pages={437-41} }