Effect of prior morphine-3-glucuronide exposure on morphine disposition and antinociception.

@article{Ouellet1997EffectOP,
  title={Effect of prior morphine-3-glucuronide exposure on morphine disposition and antinociception.},
  author={Dain{\`e}le M. -C. Ouellet and Gary M. Pollack},
  journal={Biochemical pharmacology},
  year={1997},
  volume={53 10},
  pages={
          1451-7
        }
}
Morphine-3-glucuronide (M3G), the primary metabolite of morphine in humans and rats, has been reported to antagonize morphine-induced pharmacologic effects. The present experiment was conducted to evaluate the effect of prior systemic M3G exposure on morphine disposition and antinociceptive response in male Sprague-Dawley rats. Saline (N = 6), low dose M3G (0.15 mg/hr, N = 7), or high dose M3G (0.30 mg/hr, N = 6) was infused for 720 min prior to the administration of morphine by i.v. bolus (2… CONTINUE READING

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