Effect of prior infection with virulent Shigella flexneri 2a on the resistance of monkeys to subsequent infection with Shigella sonnei.

@article{Formal1991EffectOP,
  title={Effect of prior infection with virulent Shigella flexneri 2a on the resistance of monkeys to subsequent infection with Shigella sonnei.},
  author={Samuel B. Formal and Edwin V. Oaks and Rolf Olsen and M Wingfield-Eggleston and Philip J. Snoy and Jonathan Cogan},
  journal={The Journal of infectious diseases},
  year={1991},
  volume={164 3},
  pages={533-7}
}
All virulent shigellae have large plasmids. Plasmid-associated genes encode the expression of membrane-associated proteins (MAP), some of which correlate with the ability to invade susceptible epithelial cells. These MAP are serologically related in all of the shigella serotypes and evoke an antibody response after infection. To determine whether the MAP have a significant role in protection, 24 monkeys were infected with virulent Shigella flexneri 2a. After recovery, one group (with controls… CONTINUE READING

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