Effect of primary emulsions on microsphere size and protein-loading in the double emulsion process.

@article{Maa1997EffectOP,
  title={Effect of primary emulsions on microsphere size and protein-loading in the double emulsion process.},
  author={Yilin Maa and Chung C. Hsu},
  journal={Journal of microencapsulation},
  year={1997},
  volume={14 2},
  pages={225-41}
}
Incorporation of a protein drug in microspheres made of a hydrophobic polymer is commonly achieved via double liquid-liquid emulsification (w/o/w) or by dispersing a powdered protein in a polymer solution followed by liquid-liquid emulsification (s/o/w). This study focused on the effect of the first operating step in both processes on the size and protein-loading of the microspheres. Bovine serum albumin (BSA) was used as the model protein and poly(methyl methacrylate) (PMMA) was used as the… CONTINUE READING