Effect of pretreatment of food gluten with prolyl endopeptidase on gluten-induced malabsorption in celiac sprue.

BACKGROUND & AIMS We sought to determine whether prolyl endopeptidase (PEP) treatment of food gluten would obviate the intestinal dysfunction produced by small amounts of dietary gluten supplement in patients with celiac sprue. METHODS Twenty asymptomatic patients with histologically proven celiac sprue completed a randomized, double-blind, cross-over… CONTINUE READING