Effect of pressure and timing of contraction on human diaphragm fatigue.

  title={Effect of pressure and timing of contraction on human diaphragm fatigue.},
  author={François Bellemare and Alejandro Grassino},
  journal={Journal of applied physiology: respiratory, environmental and exercise physiology},
  volume={53 5},
The relationship between the mean transdiaphragmatic pressure swing developed with each inspiration (Pdi) and the fraction of the breathing cycle time spent in inspiration (TI/Ttot) (Pdi X TI/Ttot) was related to the maximal time that such a run could be sustained (Tlim). Four normal subjects breathed with a constant breathing pattern for 45 min or until Pdi could no longer be sustained, whichever came first. The breathing patterns included Pdi of 0.15-0.90 of Pdimax and TI/Ttot of 0.15-1.0… CONTINUE READING
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