Effect of prepartum blockade of microtubule formation on ultrastructural differentiation on the mammary epithelium in holstein heifers.

@article{Nickerson1983EffectOP,
  title={Effect of prepartum blockade of microtubule formation on ultrastructural differentiation on the mammary epithelium in holstein heifers.},
  author={Stephen C. Nickerson and Robert Michael Akers},
  journal={The International journal of biochemistry},
  year={1983},
  volume={15 6},
  pages={
          777-88
        }
}
1. Prepartum infusion of colchicine into mammary quarters of heifers inhibited normal development of bovine mammary secretory tissue. 2. In comparison with control, tissue from colchicine-infused quarters exhibited 22.6% less alveolar luminal area and 17.1% more interalveolar connective tissue area indicating a reduction in secretory activity. 3. Cytological analysis demonstrated that undifferentiated cells predominated in treated quarters whereas the majority of cells in control quarters were… CONTINUE READING
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