[Effect of preparations on the intracellular cAMP and prostaglandin E content and on the functional activity of antigen-induced B-suppressors].

Abstract

Not adhering to a plastic, B-cells of intact or immunized with the suboptimal dose of ram erythrocytes mice were treated in vitro with several agonists and antagonists of cAMP and prostaglandins E and then were transferred to syngenic or allogenic unirradiated recipients. Afterwards the number of the antibody-forming cells against ram erythrocytes was determined. It was shown that a decrease of cAMP and prostaglandin E contents in the intact B-cells results in the appearance of the ability to stimulate the immune response. An increase of cAMP content in the immune B-cells is followed by a reduction of their suppressing activity. The absence of the relationship between this activity and prostaglandin E content in the immune cells is suggested.

Cite this paper

@article{Borisova1988EffectOP, title={[Effect of preparations on the intracellular cAMP and prostaglandin E content and on the functional activity of antigen-induced B-suppressors].}, author={L S Borisova and Alexander Kalinkovich and S M Inzhevatkina and M M Zakirov and M. M. Gol'dshtein}, journal={Farmakologiia i toksikologiia}, year={1988}, volume={51 6}, pages={65-9} }