• Corpus ID: 25943436

Effect of prenatal PAH exposure on birth outcomes and neurocognitive development in a cohort of newborns in Poland. Study design and preliminary ambient data.

  title={Effect of prenatal PAH exposure on birth outcomes and neurocognitive development in a cohort of newborns in Poland. Study design and preliminary ambient data.},
  author={Wiesław A. Jędrychowski and Robin M. Whyatt and David E. Camann and Ulka V Bawle and Kostia Peki and John D. Spengler and Thomas S Dumyahn and Agnieszka Penar and F Perera},
  journal={International journal of occupational medicine and environmental health},
  volume={16 1},
Preliminary data suggest an association between infant mortality rates and several measures of ambient air pollution, including dustfall and polycyclic aromatic hydrocarbons (PAH). The effects of airborne PAH components on fetal growth and early childhood development are of primary interest since we have previously demonstrated that these pollutants were associated with significant decrements in birthweight, length and head circumference in Polish newborn babies. The undertaken research… 

Figures and Tables from this paper

Prenatal exposure to polycyclic aromatic hydrocarbons and cognitive dysfunction in children

Evidence is provided that PAHs are harmful to the developing fetal brain with effects extending through childhood, with implications for the academic success of the children.

The relationship between prenatal exposure to airborne polycyclic aromatic hydrocarbons (PAHs) and PAH–DNA adducts in cord blood

The results support other findings that transplacental exposure to B[a]P from maternal inhalation produces DNA damage in the developing fetus and confirms the heightened fetal susceptibility to prenatal PAH exposure that should be a matter of public health concern, particularly in the highly polluted areas.

Antihistamine medication may alleviate negative effects of prenatal exposure to polycyclic aromatic hydrocarbons (PAH) on lung function in children. Birth cohort prospective study

The results of the study suggest that the intake of antihistamine medications in early childhood may inhibit the negative effect of fetal PAH exposure on lung growth and provides additional indirect evidence for the hypothesis that lung alterations in young children resulting fromPAH exposure may be caused by the allergic inflammation within lung.

Gene-environment interactions on mental development in African American, Dominican, and Caucasian Mothers and Newborns

The effects of interactions between prenatal PAH exposure and 21 polymorphisms or haplotypes in these genes on MDI at 12, 24, and 36 months among 547 newborns and 806 mothers from three different ethnic groups: African Americans, Dominicans, and Caucasians are explored.



Recent developments in molecular epidemiology: A study of the effects of environmental polycyclic aromatic hydrocarbons on birth outcomes in Poland.

Data from a recent study of the developmental effects of fetal exposure to polycyclic aromatic hydrocarbons via ambient pollution provides a new molecular link between PAH exposure and developmental effects, generating initial data and hypotheses for further study.

Association between air pollution and low birth weight: a community-based study.

The data suggests that TSP and SO2, or a more complex pollution mixture associated with these pollutants, contribute to an excess risk of low birth weight in the Beijing population.

Acute effects of total suspended particles and sulfur dioxides on preterm delivery: a community-based cohort study.

It is concluded that high levels of total suspended particulates and sulfur dioxide, or of a more complex pollution mixture associated with these pollutants, appear to contribute to excess risk of preterm delivery in this population of Beijing women.

The relationship between selected causes of postneonatal infant mortality and particulate air pollution in the United States.

It is suggested that particulate matter is associated with risk of postneonatal mortality and continued attention should be paid to air quality to ensure optimal health of infants in the United States.

Infertility in mice exposed in utero to benzo(a)pyrene.

Fertility was markedly impaired in F, animals exposed in utero to 10 mg BP/kg and was associated with marked alterations in gametogenesis and folliculogenesis and a dramatic decrease in the size of the gonads.

The murine Ah locus: in utero toxicity and teratogenesis associated with genetic differences in benzo[a]pyrene metabolism.

It was shown that allelic differences at the Ah locus in the fetus can be correlated with dysmorphogenesis and the fact that the mother and the father both must be of a particular genotype before differences in teratogenesis among fetuses will be expressed.

Teplice program--the impact of air pollution on human health.

Investigation and assessment of the impact of air pollution on the health of the population in the district of Teplice, Czech Republic found an excess prevalence of low birth weight and premature births and measures of semen quality suggest that exposure to high levels ofAir pollution are associated with transient decrements in semen quality.

Neonatal toxicity in mice associated with the Ahb allele following transplacental exposure to 3-methylcholanthrene.

Cocaine/polydrug use in pregnancy: two-year follow-up.

Head size in the two drug-exposed groups remained significantly smaller than in control infants through 2 years of age, and cocaine exposure was found to be the single best predictor of head circumference.