Effect of pregnancy as a risk factor for breast cancer in BRCA1/BRCA2 mutation carriers.

  title={Effect of pregnancy as a risk factor for breast cancer in BRCA1/BRCA2 mutation carriers.},
  author={Carey A Cullinane and Jan A. Lubiński and Susan L. Neuhausen and Parviz Ghadirian and Henry T. Lynch and Claudine Isaacs and Barbara K. Weber and Pal Moller and Kenneth Offit and C Kim-sing and Eitan Friedman and Susan Armel Randall and Barbara Pasini and Peter J. Ainsworth and Ruth Gershoni-baruch and William D Foulkes and Jan Klijn and Nadine Tung and Gadi Rennert and Olufunmilayo I. Olopade and Fergus J. Couch and Teresa Wagner and H{\aa}kan Olsson and Ping Sun and Jeffrey N. Weitzel and Steven A Narod},
  journal={International journal of cancer},
  volume={117 6},
Early age at first birth and multiparity have been associated with a decrease in the risk of breast cancer in women in the general population. We examined whether this relationship is also present in women at high risk of breast cancer due to the presence of a mutation in either of the 2 breast cancer susceptibility genes, BRCA1 or BRCA2. We performed a matched case-control study of 1,260 pairs of women with known BRCA1 or BRCA2 mutations, recruited from North America, Europe and Israel. Women… CONTINUE READING
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