Effect of preexisting immunity to adenovirus human serotype 5 antigens on the immune responses of nonhuman primates to vaccine regimens based on human- or chimpanzee-derived adenovirus vectors.

@article{McCoy2007EffectOP,
  title={Effect of preexisting immunity to adenovirus human serotype 5 antigens on the immune responses of nonhuman primates to vaccine regimens based on human- or chimpanzee-derived adenovirus vectors.},
  author={Kimberly C McCoy and N. C. Tatsis and Birgit Korioth-Schmitz and Marcio O. Lasaro and Scott E Hensley and Shih-wen Lin and Yan Li and Wynetta Giles-Davis and Ann S Cun and Dongming Zhou and Zhiquan Xiang and Norman L. Letvin and Hildegund C J Ertl},
  journal={Journal of virology},
  year={2007},
  volume={81 12},
  pages={
          6594-604
        }
}
In this study we compared a prime-boost regimen with two serologically distinct replication-defective adenovirus (Ad) vectors derived from chimpanzee serotypes C68 and C1 expressing Gag, Pol, gp140, and Nef of human immunodeficiency virus type 1 with a regimen in which replication-defective Ad vectors of the human serotype 5 (AdHu5) were given twice. Experiments were conducted in rhesus macaques that had or had not been preexposed to antigens of AdHu5. There was no significant difference in T… CONTINUE READING

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