Effect of precise mechanical loading on fibroblast populated collagen lattices: morphological changes.

@article{Eastwood1998EffectOP,
  title={Effect of precise mechanical loading on fibroblast populated collagen lattices: morphological changes.},
  author={Mark Eastwood and Vivek C. Mudera and D. Angus Mcgrouther and RobertA. Brown},
  journal={Cell motility and the cytoskeleton},
  year={1998},
  volume={40 1},
  pages={
          13-21
        }
}
The contraction of a collagen lattice by resident fibroblasts causes strains to be developed within that lattice. These strains can be increased or decreased by altering the aspect ratio (ratio of length/width/thickness) of the fibroblast populated collagen lattice, as the cross-sectional area resisting the strain is changed and by the application of an external load. The fibroblasts align themselves with the direction of the maximum principle strain; in effect, these cells are "hiding" from… CONTINUE READING
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