Effect of precipitated morphine withdrawal on post‐translational processing of prothyrotropin releasing hormone (proTRH) in the ventrolateral column of the midbrain periaqueductal gray

@article{Nillni2002EffectOP,
  title={Effect of precipitated morphine withdrawal on post‐translational processing of prothyrotropin releasing hormone (proTRH) in the ventrolateral column of the midbrain periaqueductal gray},
  author={E. Nillni and A. Lee and G. Légrádi and R. Lechan},
  journal={Journal of Neurochemistry},
  year={2002},
  volume={80}
}
We have demonstrated that during opiate withdrawal, preprothyrotropin releasing hormone (preproTRH) mRNA is increased in neurons of the midbrain periaqueductal gray matter (PAG) while the concentration of TRH remained unaltered, suggesting that the processing of proTRH may be different in this region of the brain. The aim of the present study was to determine which of the proTRH‐derived peptides are affected by opiate withdrawal in the PAG. These changes were compared to other TRH‐containing… Expand
Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone.
The biosynthesis and processing of neuropeptides: lessons from prothyrotropin releasing hormone (proTRH).
  • M. Perello, E. Nillni
  • Chemistry, Medicine
  • Frontiers in bioscience : a journal and virtual library
  • 2007
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