Effect of pre-treatment with simvastatin in aged rats with abdominal sepsis

@inproceedings{Medeiros2014EffectOP,
  title={Effect of pre-treatment with simvastatin in aged rats with abdominal sepsis},
  author={Aldo Cunha Medeiros and Mariana Coelho Costa and Emily Ramos Calife and Marianna Santos Tinoco da Costa and Am{\'a}lia C{\'i}nthia Meneses R{\^e}go and V{\'i}tor Brasil Medeiros and Irami Ara{\'u}jo-Filho and Mar{\'i}lia Daniela Ferreira Carvalho},
  year={2014}
}
Background/purpose: Sepsis is a severe inflammatory disease, high-risk, representing the immune response to infection with high morbidity and mortality. It is a particularly serious problem in the geriatric population. Advanced age is a risk factor for worsening of the infection, and the inhibition of inflammation is one of the many pleiotropic effects of statins. The objective of this study was to assess whether pretreatment with simvastatin alters the response of the elderly rat with… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 36 REFERENCES

Citrinin, an inhibitor of cholesterol synthesis.

VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Statins: the next anti-endotoxin.

  • Peter S Kruger
  • Engineering, Medicine
  • Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine
  • 2006

Clinical implications of statin event trials

  • RS Rosenson, CC Tangney
  • CurrAtheroscler Rep
  • 2002