Effect of pre-operative short course famotidine on tumor infiltrating lymphocytes in colorectal cancer: a double blind, placebo controlled, prospective randomized study.

@article{Kapoor2005EffectOP,
  title={Effect of pre-operative short course famotidine on tumor infiltrating lymphocytes in colorectal cancer: a double blind, placebo controlled, prospective randomized study.},
  author={Sorabh Kapoor and Sujoy Pal and Peush Sahni and Siddharth Dattagupta and Tushar Kanti Chattopadhyay},
  journal={The Journal of surgical research},
  year={2005},
  volume={129 2},
  pages={172-5}
}
BACKGROUND Pilot studies have shown that histamine H2 receptor antagonists augment the natural immunity against cancer in colorectal and gastric cancer by enhancing lymphocytic infiltration in the tumors. However, a study of adjuvant ranitidine failed to show a significant benefit in colorectal cancer, possibly because of the immunosuppression exerted by blood transfusion and post-operative infections. The pre-operative use of H2 receptor antagonists may therefore be of greater benefit. Except… CONTINUE READING

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